Chicken Pot Pie Bubble Up
This chicken bubble up is the ultimate comfort food. With creamy sauce, golden biscuits, and full of of chicken, veggies, and cheese, it’s like classic pot pie but easier!

This casserole brings together all the yummy flavors of a classic chicken pot pie but with a fun and easy bubble-up casserole twist.
This is really like an old fashioned mixed vegetable casserole but with chicken added. Comfort food, am I right? Plus, bubble up is fun to say.
It’s perfect for busy weeknights because it uses pantry staples you already have in the pantry or you can quickly grab from the store on the way home.
And if you have any leftover chicken and veggies hanging out in the fridge, it’s a great way to use them up. And I love using up leftovers.
It makes its own creamy sauce when it bakes, but it’s really the flaky biscuit topping that gets me every time!
Speaking of biscuits, I love to use them in my French onion chicken casserole and my Pillsbury biscuits and gravy casserole recipes. Try them soon!

Why is it called a bubble up?
The term “Bubble Up” in the context of this recipe refers to a type of casserole that includes pieces of refrigerated biscuit dough.
The name likely comes from the way the biscuit pieces “bubble up” as they bake and expand in the oven, giving the dish a bubbly appearance on top.
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See recipe card for complete information on ingredients and their quantities.
Ingredient Notes
- Chicken – I like to use cooked and diced chicken breasts. Or grab a rotisserie chicken from the deli for easy prep.
- Condensed soup – I prefer cream of chicken soup. Sub cream of mushroom if preferred.
- Sour cream – Substitute plain Greek yogurt.
- Vegetables – Frozen mixed vegetables or use a combo of your favorite ones.
- Biscuits – Refrigerated biscuits (10 count works best)
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Variations and Substitutions
- Substitute the chicken for turkey or ham. Great way to use up holiday leftovers!
- Try using cream of mushroom, cream of celery, or cream of potato soup. I personally love a broccoli cheese soup like in this skillet pot pie recipe.
- Frozen mixed vegetables work best but use your favorite combination of veggies. Try carrots, peas, green beans, corn, or diced potatoes.
- Try puff pastry or crescent roll dough if you’d like to experiment with the “crust” topping.
- Mix in additional seasonings like poultry seasoning, chicken seasoning, or Italian seasoning.
- Try your favorite cheeses like American, mozzarella, or even Pepper Jack.
How To Make Chicken Pot Pie Bubble Up

- Preheat oven to 350F. Prepare a 9×13 casserole dish with nonstick cooking spray. In a large mixing bowl, combine the chicken, soup, sour cream, garlic and onion powder.

- Stir to combine. Fold in the mixed vegetables and cheddar cheese.

- Cut the biscuits into quarters. Fold the pieces into the chicken mixture gently. Spread into the prepared 9×13 pan.

- Bake for about 35-45 minutes or until bubbly and the biscuits are golden brown. Remove and let cool for 2-3 minutes to set up. Serve warm.
For the full recipe and detailed cooking instructions, please see the recipe card at the end of this post.

Storage & Reheating
You can store leftover casserole in the refrigerator in an airtight container for about 3-4 days.
Oven: Reheat in a 350F oven for 15-20 minutes or until heated through. Cover with aluminum foil to prevent the top from burning or getting too crispy.
Microwave: Heat leftovers in the microwave for 1-2 minutes or until heated through. This method is faster but you might lost some of the crispy texture of the biscuit topping.
My personal preference is to microwave a single portion for 1 minute in the microwave and then crisp it up in the air fryer for 3-4 minutes at 350F.

How To Freeze
Before Baking: Combine all the casserole ingredients, minus the biscuits, and place in the baking dish. Cover tightly with plastic wrap, then with foil, and freeze it.
When ready to cook, remove from the freezer, thaw in the refrigerator overnight. Add the biscuit pieces, and then bake according to the original instructions.
After Baking: Assemble and bake the whole casserole according to recipe directions. Let it cool completely at room temperature. Transfer the cooled leftovers to an airtight, freezer-safe container or a heavy-duty freezer bag, and freeze.
When you’re ready to eat, thaw the leftovers in the refrigerator overnight and reheat in the oven or microwave.
Note that the biscuits may change in texture after being frozen and reheated. They may not be as fluffy or crisp as when freshly made.

Make Ahead
Yes you can! Just prep as usual and cover with plastic wrap and refrigerate overnight. The only change I would make is to leave the biscuits out until ready to bake.
In my experience the biscuits don’t rise as nicely if you put them in the casserole the night before.
Serving Suggestions
All the yummy ingredients makes this a complete dinner. But if you want sides, I love serving this Chicken Pot Pie Bubble Up with a simple salad or extra vegetables like roasted broccoli or asparagus.

Biscuit Substitutes
Crescent rolls have a slightly different flavor and texture – they are a bit lighter and more flaky compared to biscuit dough – but they can still work well in this dish.
Remember, the key is to make sure the dough is fully cooked and not doughy when you pull it out of the oven. The top should be golden brown and the casserole should be bubbling.
You can also use pie crust instead of biscuits. The result will be more like a traditional pot pie but still very delicious.
Roll out the pie crust and cut it into small pieces, or cover the top of the dish with a whole pie crust. Cut a few slits in the crust to allow steam to escape during baking.
Bake the dish at the same temperature, but you might need to adjust the baking time. Start checking at around 25 minutes. The crust should be golden brown and the filling should be bubbly when it’s done.

Yes, you can definitely use homemade biscuits in this recipe. Just prepare your biscuits like you normally would and then incorporate into the recipe as usual.
Casseroles with Biscuits
I love using biscuits in my recipes because they are inexpensive and you can really stretch the meal to feed a crowd, or a hungry family.
Some of my other favorite casseroles with biscuits are my French onion chicken casserole and my biscuit and gravy casserole.

Tips For The Best Casserole
- Add ½ the biscuit pieces into the mix and scatter the remaining ones on top for more of a crust look.
- I prefer the regular size biscuits but you can use the larger ones. Might need to cut them into 6 pieces so they cook evenly.
- Flaky layers or homestyle are the best texture. Buttermilk biscuits work well too.
- Substitute cream cheese for the sour cream.
- Try different cream or condensed soups for more flavor. Just like in this chicken potato broccoli casserole with cream of chicken soup. It makes it so creamy and adds flavor!
- Use canned or rotisserie chicken. Can use chicken thighs if desired. I have not tested this using raw chicken.
- Canned vegetables are a quick option but might become mushy during the baking. If you use them, be sure to rinse and drain them really well.
- If you only have fresh vegetables, blanch or steam them before adding to the casserole.
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When you’re in the mood for a comfort food and a meal that the whole family will love, this Chicken Pot Pie Bubble Up is the perfect choice.

Chicken Pot Pie Bubble Up Casserole Recipe
Equipment
Ingredients
- 2 ½ cups cooked chicken diced or shredded
- 1 10.5 ounce can cream of chicken soup
- 8 ounces sour cream
- 1 teaspoon garlic powder
- ½ teaspoon onion powder
- 2 cups frozen mixed vegetables
- 2 cups shredded cheddar cheese
- 1 12 ounce can refrigerated biscuits (10 count)
Instructions
- Preheat oven to 350F. Prepare a 9×13 baking dish with nonstick spray
- In a large mixing bowl, combine the chicken, soup, sour cream, garlic and onion powder.
- Stir to combine.
- Fold in the mixed vegetables and cheddar cheese.
- Cut the biscuits into quarters.
- Fold the pieces into the chicken mixture gently.
- Spread into the prepared 9×13 pan.
- Bake for 35-45 minutes or until bubbly and the biscuits are golden brown.
- Remove and let cool for 2-3 minutes to set up. Serve warm.
Notes
- Incorporate ½ the biscuit pieces into the mix and scatter the remaining ones on top for more of a crust look.
- I prefer the regular biscuits but you can use the larger ones. Might need to cut them into 6 pieces so they cook evenly.
- Flaky layers or homestyle are the best texture. Buttermilk biscuits work well too.
- Add extra cheese if you love cheese!
- Substitute cream cheese for the sour cream.
- Try different cream or condensed soups for more flavor.
- Add different seasonings to change the flavor profile.
- Use canned or rotisserie chicken. Can use chicken thighs if desired. I have not tested this using raw chicken.
- Canned vegetables are a quick option but might become mushy during the baking.
- If you only have fresh vegetables, blanch or steam them before adding to the casserole.
Nutrition
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